HMGB1 (D3E5) Rabbit mAb 6893S from Cell Signaling Technology

Product Specs
ItemHMGB1 (D3E5) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number6893S
Quantity100 µl
ApplicationsW, IHC-P
ReactivityH, M, R, Mk
TargetHMGB1
HostRabbit
NCBI Gene AliasesHMG-1, HMG1, HMG3, SBP-1
ClonalityMonoclonal
NCBI Full Gene Namehigh mobility group box 1
Research AreaChromatin Regulation / Nuclear Function
IsotypeIgG
CloneD3E5
Molecular Weight29

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Hydrogen sulfide ameliorates peritoneal fibrosis: inhibition of high mobility group box-1 expression to block the activation of the transforming growth factor-beta/Smad3 pathwayMedical Gas ResearchJune 1, 2026Lulu Liu, Weiyan Huang, Jiao Ming, Fei Cai, Haiyan Wang, Xueli Lai, Zhiyong Guoovernight at 4°C, including high mobility group box 1 (HMGB1; rabbit, 1:200, CST, Danvers, MA, USA, Cat# 6893, RRID: AB_10827882), TGF-β1 (rabbit, 1:200, Abways, Shanghai, China, Cat# CY6608, RRID: AB_3663010),

(2) Tumor‐Bearing Status Accelerates Bleomycin‐Induced Pulmonary Inflammation via Endothelial ActivationThoracic CancerApril 1, 2026Shoko Isoyama, Kakuhiro Yamaguchi, Hiroshi Iwamoto, Yasushi Horimasu, Kunihiko Funaishi, Kiyofumi Shimoji, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Shinichiro Ohshimo, et al.sections. Subsequently, the tumor sections were stained with anti‐HMGB1 antibody (1:400 dilution, cat#6893; Cell Signaling Technology, Danvers, MA, USA). Stained slides were scanned using a microscope (cat.

(3) Iodine-125 brachytherapy triggers immunogenic cell death and potentiates anti-PD-L1 immunotherapy in bone metastatic triple-negative breast cancerFrontiers in ImmunologyMarch 31, 2026Min Li, Zhenzhen Cui, Jiaxin Yang, Qiyu Sun, Yanbo Hu, Juan Shen, Zhihao Li, Xiaoyang Han, Yixuan Wang, Jiageng Tang, et al.at room temperature, and incubated overnight at 4°C with primary antibodies against HMGB1 (1:1000, #6893, CST), CALR (1:1000, #12238, CST), Flotillin-2 (1:1000, #3436, CST), and β-actin (1:2000, #10624-2-AP,

(4) Pyroptosis Modulates Multiple Immune Cell Populations in Targeted Therapy–Treated MelanomaCancer Immunology ResearchJanuary 22, 2026Nicole A. Wilski-Cronin, Dan A. Erkes, Timothy J. Purwin, Diana S. Melissaratos, Casey D. Stefanski, Signe Caksa, Erica Kitterman, Jacob S. Heilizer, Inna Chervoneva, Teresa Fernandes-Alnemri, et al.ERK1/2 (Cell Signaling Technologies, #9102, RRID: AB_330744), HMGB1 (Cell Signaling Technology, Cat. #6893, RRID: AB_10827882), vinculin (Santa Cruz Biotechnology, Cat. #sc-73614, RRID: AB_1131294), and β-actin

(5) SIGLEC12 mediates plasma membrane rupture during necroptotic cell deathNatureJanuary 8, 2026Hyunjin Noh, Zeena Hashem, Elena Boms, Ayaz Najafov(Cell Signaling Technology, catalogue no. 84382); anti-HMGB1 (Cell Signaling Technology, catalogue no. 6893); anti-β-actin (Sigma-Aldrich, A5316); anti-FLAG (Sigma-Aldrich, F1804); anti-FLAG–HRP (Cell Signaling Technology

(6) CD38 Inhibition Ameliorates Age-Related Cognitive Decline via a Choroid Plexus–Cerebrospinal Fluid–Hippocampus AxisResearch SquareJanuary 6, 2026Eric Verdin, Jingqi Fang, Rebeccah Riley, Kevin Schneider, Rosalba Perrone, Prasanna Kumaar, Christina King, Grant Kauwe, Andrea Roberts, Genesis Vega Hormazabal, et al.Abcam ab216343; 1:500, R&D Systems AF4947), p21 (1:200, Abcam ab188224), HMGB1 (1:200, Cell Signaling 6893), TTR (1:500, Abcam ab215202; 1:200, Thermo Fisher Scientific 66108-1-1G), CD13 (1:200, Cell Signaling

(7) Mechanism of Hypoxia-Induced HMGB1 Regulating NLRP3 Inflammasome/Caspase-1 Pathway-Mediated Pyroptosis in Myocardial Ischemia Reperfusion Injury Through the Nrf2/HO-1 PathwayCNS Neurosci TherDecember 11, 2025Fuzhen Zheng, Licheng Yan, Fei Ren, Wenlong Cai, Yongrong Lan, Hong Chen, Qian Chen, Guoxing Wengendogenous peroxidase inactivation, sections were fostered with primary antibodies against HMGB1 (1:100, #6893, Cell Signaling), Nrf2 (1:100, #41255, Signalway Antibody, College Park, MD, USA), HO‐1 (1:200, ab189491,

(8) Integrative prognostic model incorporating high mobility group box 1 subcellular localization and tumor-infiltrating lymphocytes in early-stage lung adenocarcinomaDiagn PatholDecember 1, 2025Yao Liu, Miyako Shimasaki, Motona Kumagai, Jia Han, Akihiro Shioya, Masaru Sakurai, Hidetaka Uramoto, Sohsuke Yamadaμm. Immunohistochemical staining for HMGB1 was performed using a primary anti-HMGB1 antibody (Code: 6893; Cell Signaling Technology, Danvers, MA, USA) at a dilution of 1:1000 following standard heat-induced

(9) Enterococcus-derived cytolysin exacerbates ischemic stroke by disrupting the blood–brain barrier via NLRP3 activationJournal of NeuroinflammationNovember 11, 2025Jia-ni Huang, Wei-hao Zhuang, Yi-si Lin, Jia-xue Xu, Yan-lei Zhang, Jia Li, Meng Huang, Cheng-long Xie, Ruo-ting XuCell Signaling Technology), anti-ASC rabbit mAb (1:1000, #67824, Cell Signaling Technology), anti-HMGB1 rabbit mAb (1:1000, #6893, Cell Signaling Technology), recombinant anti-IL-18 antibody (1:1000, ab207323, Abcam), anti-NLRP3 antibody

(10) HMGB1 mediated autophagy and apoptosis in human nucleus pulposus cells; chloroquine amplified apoptosis by inhibiting autophagyScientific ReportsNovember 10, 2025Md Abdul Khaleque, Ga-Hyun Kim, Do-Kyun Kim, Md Amit Hasan Tanvir, Hwan-Hee Lee, Young-Yul Kimused: LC3B (1:1000, NB100-2220, Novus Biologicals USA), P62 (1:1000, ab56416, Abcam), HMGB1 (1:1000, 6893, Cell Signaling Technology, Massachusetts, USA), Cleaved caspase-3 (1:1000, NB100-56113, Novus Biologicals

(11) Protective effects of melatonin on stroke in diabetic mice: central and peripheral inflammation modulationStroke Vasc NeurolOctober 27, 2025Cuiying Liu, Jiayi Guo, Longfei Guan, Junfa Li, Baohui Xu, Heng Zhaofrom Cell Signaling Technology (CST) including NLRP3 (#15101), p-ERK (#4370), ERK (#4695), HMGB1 (#6893), Cleaved Caspase-1 (#89332) and Actin (#4970) Statistical analysis All continuous variables were

(12) HMGB-1 Increases Proinflammatory Reaction via TLR4 in Human Granulosa Cells of EndometriosisJournal of Clinical MedicineOctober 24, 2025Hye In Kim, Kyung Hee Kim, SiHyun Cho, Young Sik Choi, Byung Seok Lee, Seung Joo Chon, Bo Hyon Yunanti-mouse antibody; 66009, Proteintech, Rosemont, IL, USA), HMGB-1 (polyclonal anti-rabbit antibody; 6893, Cell Signaling Technology, Danvers, MA, USA), TLR4 (polyclonal anti-rabbit antibody; GTX21436, GeneTex,

(13) Selective USP7 Inhibition Synergizes with MEK1/2 Inhibitor to Enhance Immune Responses and Potentiate Anti–PD-1 Therapy in NRAS-Mutant MelanomaJournal of Investigative DermatologyOctober 1, 2025Liya Su, Dinghao Wang, Timothy J. Purwin, Sophia Ran, Qi Yang, Qingrun Zhang, Weijia Cai(#4696), p-S6 (S240/244, #2215), p-S6 (S235/236, #4857), S6 (#2217), caspase-3 (#9662) and HMGB1 (#6893) were purchased from Cell Signaling Technology. The antibody for GSDME (ab215191) was purchased from

(14) Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathwayBiol DirectAugust 22, 2025Wei Wang, Lijiang Zhou, Xinyu Zhang, Zheng LiTechnology), anti-Ki67 (BF0132; Affinity Biosciences), anti-CRT (ab195511; Abcam), anti-HMGB1 antibody (6893; Cell Signaling Technology) overnight. Samples were incubated with secondary antibodies (S0001, S0002;

(15) Nanoparticle conjugation of ginsenoside Rh2 enhanced antitumor efficacy on hepatocellular carcinomaSci RepAugust 8, 2025Fengkai Sun, Jinkun Liu, Shuai Gao, Mingchen Zhang, Xiaoyan Sun, Yanan Tian, Shengchun Wanganti-Vimentin (1:20000, 10366-1-AP, Proteintech), anti-Calreticulin (1:1000, 12238, CST), anti-HMGB1 (1:1000, 6893, CST), Anti-HSP70 (1:1000, 4872, CST), and anti-HSP90 (1:3000, 13171-1-AP, proteintech). Statistical

(16) Syncytial death mediated by oncolytic rVSV-NDV dynamically activates immunogenic apoptosis and necroptosis in human lung cancer cellsMol Ther OncolAugust 5, 2025Fabian Kortum, Nina Hartmann, Alexander Bryan, Sonja Glauß, Jennifer Altomonterabbit anti-HSP90 (#4874, CST), rabbit anti-CRT (D3E6) XP (#12238, CST), rabbit anti-HMGB1 (D3E5) (#6893, CST), and processed as described above. Protein was quantified relative to a total protein Ponceau-S

(17) Higher expression of high-mobility group box 1 in cholangiocarcinoma and association with cell growth, in vitro migration and invasion, and chemo-drug sensitivitySci ProgJuly 21, 2025Arunya Jiraviriyakul, Samitanan Promchai, Chatchai Nensat, Suphakit Khutanthong, Nun Singpan, Worawat Songjangmarker, samples, antibody diluent, specific primary antibodies dilution for 1:300 (including anti-HMGB1; 6893, anti-pAkt; 4060, anti-Akt; 9272, anti-pERK; 4370, anti-ERK; 4695, anti-cyclin D1; 9278, and anti-β-actin;

(18) Engineered Oncolytic Virus OH2-FLT3L Enhances Antitumor Immunity via Dendritic Cell ActivationMolecular Therapy OncologyJune 18, 2025Duo Wan, Qi Zhang, Zhenrong Yang, Xiaoli Zhang, Peipei Xie, Shujun Cheng, Libin Xu, Binlei Liu, Kaitai Zhang, Wen ZhangBiosciences, A72794) at a dilution of 1:1,000, HMGB1 (D3E5) Rabbit mAb (Cell Signaling Technology #6893) at a dilution of 1:1,000, Beta Actin Rabbit mAb [SLMD] (Nature Biosciences, RA0001) at a dilution of

(19) GPX4-dependent ferroptosis sensitivity is a fitness trade-off for cell enlargementiScienceMay 16, 2025Kuan Yoow Chan, Yini Yu, Yidi Kong, Ling Cheng, Renzhi Yao, Phoebe Sha Yin Chair, Ping Wang, Rong Wang, Wan-Yang Sun, Rong-Rong He, et al.RRID:AB_2183598 anti-CALR,ZenBio,R380959 anti-REEP5,ABclonal,A10392; RRID:AB_2757940 anti-HMGB1,Cell Signaling Technology,6893; RRID:AB_10827882 anti-LMNB1,Cell Signaling Technology,17416; RRID:AB_3095982 anti-Ki67,Beyotime,AF1738;

(20) Epigenetic modulation of the NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infectionCell communication and signaling : CCSApril 25, 2025Premadasa LS, McDew-White M, Romero L, Gondo B, Drawec JA, Ling B, Okeoma CM, Mohan M.dilution), p-MLKL(Ser358) (GeneTex; GTX00973, 1:100 dilution), and HMGB1 (D3E5) (Cell Signaling Technology: 6893; 1:50 dilution). At least eight areas per tissue section for each RM were scanned using a Zeiss LSM800

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HMGB1 (D3E5) Rabbit mAb

HMGB1 (D3E5) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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HMGB1 (D3E5) Rabbit mAb from Cell Signaling Technology

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