Elsilimomab HY-P99287 from MedChemExpress | Biocompare.com

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Elsilimomab

Description

Elsilimomab (B-E8) is a IgG1 monoclonal antibody against interleukin-6 (IL-6), with a K_D of 22 pM and an IC₅₀ of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA)

Product Specs
ItemElsilimomab
CompanyMedChemExpress
Price $290.00Supplier Page View Company Product Page
Catalog NumberHY-P99287
Quantity1 mg
TypeChemical
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.44%
Research AreaInflammation/Immunology; Cancer

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(1) Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growthHaematologicaFebruary 1, 2017Burger R, Günther A, Klausz K, Staudinger M, Peipp M, Penas EM, Rose-John S, Wijdenes J, Gramatzki M.

(2) A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancerMolecular therapy : the journal of the American Society of Gene TherapyJuly 1, 2014Lee JJ, Kim HJ, Yang CS, Kyeong HH, Choi JM, Hwang DE, Yuk JM, Park K, Kim YJ, Lee SG, et al.

(3) Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokineticsJournal of molecular biologyAugust 26, 2011Finch DK, Sleeman MA, Moisan J, Ferraro F, Botterell S, Campbell J, Cochrane D, Cruwys S, England E, Lane S, et al.

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