Fig 1: Curcumin improved hippocampal neurogenesis and synaptic plasticity in mice subjected to hypoxia stress. A Fluorogram of BrdU-positive (newborn) cells in the subgranular zone-granule cell layer of the hippocampus in mice. B Histograms showing the number of BrdU-positive cells as shown in BrdU staining. C, D Representative dendritic segments of CA1 pyramidal neurons (AO = apical oblique dendrite) in each group of Thy-l-YFP mice. E Dendritic spine density expressed as the number of spines normalized to 15 μm of dendritic length. F, G Western blots of PSD95, Homer1 and BDNF in the hippocampus (the original blots/gels are presented in Supplementary Fig. 1). Histograms on the right show relative protein band density. All data are expressed as mean ± SEM, n = 3, *p < 0.05, **p < 0.01 versus Con group, #p < 0.05 versus H14d group.