EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb 3197T from Cell Signaling Technology

Product Specs
ItemEGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb
CompanyCell Signaling Technology
Price $188.00 Inquire
Catalog Number3197T
ApplicationsWB, FCM, ICC, IF, IHC-p, IP
ReactivityHuman (Hu)
NCBI Gene AliasesERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
NCBI Full Gene Nameepidermal growth factor receptor
TargetEGFR (Leu858Arg) mutation
Quantity20 µl
HostRabbit
ClonalityMonoclonal

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathwaybioRxivJune 8, 2025Esther Liu, Matthew Wright, Andrew O. Kearney, Tiffany Caza, Johnson Y. Yang, Valerie Garcia, Amal O. Dadi, Shuta Ishibe, Navdeep S. Chandel, Hanrui Zhang, et al.(3.7D6, 1:1000, Genentech), anti-B-Actin (4970, 1:5000, Cell Signaling Technologies), anti-p-PERK (3197, 1:1000, Cell Signaling Technologies) anti-PERK (3192, 1:1000, Cell Signaling Technologies), anti-IRE1a

(2) Piperlongumine in combination with EGFR tyrosine kinase inhibitors for the treatment of lung cancer cellsOncology ResearchOctober 16, 2024SHAIL RAKESH MODI, TERRICK ANDEYCell Signaling), p-EGF receptor (#2234, Cell Signaling), EGF mutant (L858R mutant specific) receptor (#3197, Cell Signaling), Cleaved Caspase 3 (#9664, Cell Signaling), Cleaved Caspase 7 (#9491, Cell Signaling),

(3) EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and GrowthCancer DiscoveryMarch 1, 2024Alexandra Kuhlmann-Hogan, Thekla Cordes, Ziyan Xu, Ramya S. Kuna, Kacie A. Traina, Camila Robles-Oteíza, Deborah Ayeni, Elizabeth M. Kwong, Stellar Levy, Anna-Maria Globig, et al.RRID:AB_2246311), αEGFRL858R mutant specific (1:100 microscopy; 1:200 for IHC) Cell Signaling Technology Cat# 3197, RRID:AB_1903955), αpEGFR (1:100; phospho Y1069) (Abcam Cat# ab205828, RRID:AB_2890267). Isotopic Tracing

(4) The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistanceNature geneticsJanuary 1, 2024Caswell DR, Gui P, Mayekar MK, Law EK, Pich O, Bailey C, Boumelha J, Kerr DL, Blakely CM, Manabe T, et al.paraffin embedding. IHC was performed using the following primary antibodies: EGFRL858R mutant specific (CST, 3197 and 43B2), APOBEC3B (5210-87-13)86, Ki67 (Abcam, Ab15580), Caspase 3 (R&D (Bio-Techne), AF835), p-Histone

(5) High-fat diet induces C-reactive protein secretion, promoting lung adenocarcinoma via immune microenvironment modulationDisease models & mechanismsNovember 1, 2023Hsu WL, Hsieh YT, Chen WM, Chien MH, Luo WJ, Chang JH, Devlin K, Su KY.transferred to PVDF membranes, and blotted with anti-EGFR L858R (1:1000, Cell Signaling Technology, 3197), anti-EGFR (1:1000, Cell Signaling Technology, 4267), anti-p-EGFR (1:1000, Cell Signaling Technology,

(6) CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR-mutated and overexpressed oral canceriScienceMarch 17, 2023Lin YC, Hua CH, Lu HM, Huang SW, Chen Y, Tsai MH, Lin FY, Canoll P, Chiu SC, Huang WH, et al.ab52894,RRID: AB_869579" EGF Receptor (L858R Mutant Specific) [43B2],Cell Signaling Technology,"Cat# 3197,RRID: AB_1903955" "Anti-NLRP3/NALP3, mAb [Cryo-2]",Adipogen Life Sciences,"Cat# AG-20B-0014-C100, RRID:

(7) Characterizing the secretome of EGFR mutant lung adenocarcinomaFrontiers in oncologyJanuary 1, 2023Luu JK, Johnson FD, Jajarmi J, Sihota T, Shi R, Lu D, Farnsworth D, Spencer SE, Negri GL, Morin GB, et al.(Cell Signaling Technology, 9122); p-EGFR(Tyr1068) (Cell Signaling Technology, 2234); EGFR L858R (Cell Signaling Technology, 3197); EGFR (Cell Signaling Technology, 2232); MKP3 (DUSP6) (Santa Cruz Biotechnology, sc-377070, 1:200);

(8) A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutationsNature communicationsNovember 14, 2022Deng H, Lei Q, Wang C, Wang Z, Chen H, Wang G, Yang N, Huang D, Yu Q, Yao M, et al.antibodies were purchased from Cell Signaling Technology (CST): EGFR wild-type (#4267), EGFR (L858R mutant, #3197), EGFR (E746-A750del, #2085), phospho-EGFR (Tyr1068, #3777), AKT (#4685), phospho-AKT (Ser473, #4060),

(9) m(6)A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancerCancer gene therapyOctober 1, 2022Tsuchiya K, Yoshimura K, Iwashita Y, Inoue Y, Ohta T, Watanabe H, Yamada H, Kawase A, Tanahashi M, Ogawa H, et al.E746-A750 deletion (#2085, D6B6, Cell Signaling Technology [CST], Danvers, MA, USA) and EGFR L858R mutant (#3197, 43B2, CST) were diluted at 1:100, followed by incubation at room temperature for 0.5 h. Protein expression

(10) EGFR Inhibition Strongly Modulates the Tumour Immune Microenvironment in EGFR-Driven Non-Small-Cell Lung CancerCancers (Basel)August 16, 2022Carolin Selenz, Anik Compes, Marieke Nill, Sven Borchmann, Margarete Odenthal, Alexandra Florin, Johannes Brägelmann, Reinhard Büttner, Lydia Meder, Roland T. Ullrichhaematoxylin and eosin (H&E), as well as primary antibodies against EGFRL858R (Cell Signaling Technologies, 3197, Leiden, The Netherlands), CD3 (Thermo Fisher, RM-9107-S, Waltham, MA, USA), CD4 (Abcam, EPR19514, Cambidge,

(11) Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinomaDisease models & mechanismsNovember 1, 2021Robles-Oteiza C, Ayeni D, Levy S, Homer RJ, Kaech SM, Politi K.retrieval, immunofluorescence staining was performed with anti-EGFRL858R antibody (Cell Signaling #3197) overnight at 4°C and fluorescent secondary for 1 h at room temperature (anti-rabbit AlexaFluor 488,

(12) Epidermal Growth Factor Receptor Mutations Carried in Extracellular Vesicle-Derived Cargo Mirror Disease Status in Metastatic Non-small Cell Lung CancerFrontiers in Cell and Developmental BiologyOctober 6, 2021Emma Purcell, Sarah Owen, Emily Prantzalos, Abigail Radomski, Nayri Carman, Ting-Wen Lo, Mina Zeinali, Chitra Subramanian, Nithya Ramnath, Sunitha Nagrath(Cell Signaling) ,, CD9,1:1000,#13174 ACTB,1:1000,#4970 GAPDH,1:1000,#5174S Calnexin,1:1000,#2679 EGF Receptor L858R Mutant Specific,1:1000,#3197 EGF Receptor exon 19 E746-A750 del specific,1:1000,#2085 "Anti-rabbit IgG, HRP-linked Antibody",1:1500,#7074S

(13) Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosisCancer cellSeptember 13, 2021Tanaka K, Yu HA, Yang S, Han S, Selcuklu SD, Kim K, Ramani S, Ganesan YT, Moyer A, Sinha S, et al.AB_2798512 Rabbit monoclonal anti-EGFR(L858R mutant specific) (43B2),Cell Signaling Technology,Cat# 3197; RRID: AB_1903955 Rabbit monoclonal anti-phospho H2A.X,Cell Signaling Technology,Cat# 9718; RRID: AB_2118009 Mouse

(14) Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In VivoCancer DiscoveryJuly 1, 2021Giorgia Foggetti et al.Mann-Whitney U test. The following antibodies were used for immunohistochemistry: anti-EGFRL858R (1:200, CST, 3197), anti-SP-C (1:200, abcam, AB40876), anti-TTF-1/Nkx2–1 (1:200, abcam, AB76013), anti-phospho-histone

(15) Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4OncogenesisMarch 12, 2021Calder J, Nagelberg A, Luu J, Lu D, Lockwood WW.(13,116), β-catenin (8480), Vimentin (5741), EGFR (2232S), Ras (8955S), EGFR (L858R mutant specific) (3197), MYC (5605), and FOSL1 (5281). From abcam; CK2α (ab137788), and from Santa Cruz; GAP (sc-47724). Lastly

(16) HTR3A is correlated with unfavorable histology and promotes proliferation through ERK phosphorylation in lung adenocarcinomaCancer scienceOctober 1, 2020Tone M, Tahara S, Nojima S, Motooka D, Okuzaki D, Morii E.using EGFR E746‐A750del (1:100, number 2085; Cell Signaling Technology) and EGFR L858R (1:100, number 3197; Cell Signaling Technology) as primary Abs, based on the criteria shown in our previous paper. 9 We

(17) Expression, intracellular localization, and mutation of EGFR in conjunctival squamous cell carcinoma and the association with prognosis and treatmentPLOS ONEAugust 24, 2020Atsushi Sakai, Mizuki Tagami, Anna Kakehashi, Atsuko Katsuyama-Yoshikawa, Norihiko Misawa, Hideki Wanibuchi, Atsushi Azumi, Shigeru Hondaantibodies, we used EGFR E746-A750del (#2085, Cell Signaling Technologies, Danvers, MA, USA) and EGFR L858R (#3197, Cell Signaling Technologies), which were manually applied to the slides. Stained sections were viewed

(18) ¹⁸F‑FDG PET/CT SUV_max and serum CEA levels as predictors for EGFR mutation state in Chinese patients with non‑small cell lung cancerOncology LettersJuly 29, 2020Xi‑can Gao, Chun‑hua Wei, Rui‑guang Zhang, Qian Cai, Yong He, Fan Tong, Ji‑hua Dong, Gang Wu, Xiao‑rong Dongcomplex method using monoclonal rabbit antibodies against the exon 21 L858R EGFR mutation (cat. no. 3197) and the 15-bp E746-750 deletion in exon 19 (cat. no. 2085) (both from Cell Signaling Technology Inc.).

(19) Novel ALK-specific mRNA in situ hybridization assay for non-small-cell lung carcinomaTranslational Lung Cancer ResearchMay 19, 2020Noriko Hirai, Takaaki Sasaki, Shunsuke Okumura, Masatoshi Sado, Naoko Akiyama, Masahiro Kitada, Hidehiro Takei, Yoshinobu Ohsakimutation-specific monoclonal antibodies [clone D6B6 (catalog number 2085) and clone 43B2 (catalog number 3197), respectively; Cell Signaling Technology]. ALK-FISH mRNA-ISH-positive samples or IHC-positive samples

(20) A neural network model predicts community-level signaling states in a diverse microbial communityPLOS Computational BiologyJune 24, 2019Kalinga Pavan T. Silva, James Q. BoedickerSperandio V. Bacterial Cell-to-Cell Signaling in the Gastrointestinal Tract. Infect Immun. 2005; 73: 3197–3209. https://doi.org/10.1128/IAI.73.6.3197-3209.2005 PMID: 15908344 20. Thompson JA, Oliveira RA,

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EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb from Cell Signaling Technology

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EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb from Cell Signaling Technology

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