MyBioSource.com's Rabbit Anti-MEK1 Antibody is a Rabbit monoclonal antibody. The Rabbit Anti-MEK1 Antibody was generated using NFKBIA as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Other.
Description
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins, which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime