The Secretory Phospholipase A2 Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to phospholipase A2 group IIA, and PLA2G2A. This antibody recognizes Human, Mouse, and Rat antigen. The Secretory Phospholipase A2 Rabbit mAb Antibody has been shown to work in the following applications: Western Blot.
Description
Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536)