The Rabbit Anti-Smad2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SMAD2. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-Smad2 Antibody has been shown to work in the following applications: Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator