The TGF beta R3 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to TGFBR3. This antibody recognizes Human antigen. The TGF beta R3 Antibody has been shown to work in the following applications: EIA, Immunoassay, and ELISA.
Description
Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 -85 kDa), and Type III (250 -350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction