MyBioSource.com's Anti-FoxP3 APC is a Mouse monoclonal antibody. The Anti-FoxP3 APC Antibody was generated using Forkhead Box P3, and FOXP3 as the antigen. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
FoxP3 (Forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome