MyBioSource.com's Phospho-Cyclin E1 (T77) Rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot. The Phospho-Cyclin E1 (T77) Rabbit pAb Antibody was generated using CCNE1, and Cyclin E1 as the antigen and it reacts with Human.
Description
Cyclin E1 and cyclin E2 can associate with and activate CDK2. Upon DNA damage, upregulatioctivation of the CDK inhibitors p21 Waf1/Cip1 and p27 Kip1 prevent cyclin E/CDK2 activation, resulting in G1/S arrest. Cyclin E1 is phosphorylated at multiple sites in vivo including Thr62, Ser88, Ser72, Thr380 and Ser384, and is controlled by at least two kinases, CDK2 and GSK-3