TLE1/2/3/4 Polyclonal Antibody from MyBioSource.com

TLE1 (Transducin Like Enhancer Of Split 1) is a Protein Coding gene. Diseases associated with TLE1 include Synovium Cancer and Spindle Cell Liposarcoma. Among its related pathways are Signaling by Wnt and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is TLE4. TLE2 (Transducin Like Enhancer Of Split 2) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is TLE1. TLE3 (Transducin Like Enhancer Of Split 3) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is TLE4.This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. TLE4 (Transducin Like Enhancer Of Split 4) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include chromatin binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is TLE1