MyBioSource.com's Rabbit Anti-ARIH1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Immunohistochemistry.
Description
ARIH1 (ariadne homolog), also known as ubiquitin conjugating enzyme E2 binding protein 1, ARI, HARI, HHARI (human homolog of Drosophila ariadne), MOP-6 (monocyte protein 6) or UBCH7BP (UBCH7 binding protein), is a 557 amino acid cytoplasmic protein. Expressed in a wide variety of tissues, ARIH1 contains two RING-type zinc fingers and one IBR (in-between RING fingers)-type domain. ARIH1 is believed to be involved in protein degradation and protein translation. ARIH1 interacts with UBCH7 and is thought to function as an E3 ubiquitin-protein ligase (or as a component of an E3 complex) that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme (UBCH7) and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, ARIH1 interacts with and polyubiquitylates eIF4E2, thereby targeting it for proteasomal degradation.This product can be used in analytical tools such as IHC, ELISA