The Rabbit Anti-SF3B4 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Rabbit Anti-SF3B4 Antibody has been shown to work in the following applications: Immunoprecipitation, and Western Blot.
Description
Splicing factor 3b subunit 4 (SF3B4) is a splicing factor and potential oncogene in hepatocellular carcinoma (HCC). SF3B4 plays a crucial role in hepatocellular carcinoma (HCC) and is negatively regulated by miRNA-133b. The miRNA-133b/ SF3B4 axis may serve as a new therapeutic target for HCC treatment. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis. Homologs of SF3b4 in other phyla are also essential. Haploinsufficiency of the SF3B4 gene has been identified as a significant reason for Nager syndrome. Mutations in the SF3B4 gene, which encodes a component of the pre-mRNA spliceosomal complex, were identified as a cause of Nager syndrome, accounting for 60% of affected individuals