The REST Antibody, HRP conjugated from MyBioSource.com is a Rabbit Polyclonal antibody to REST. This antibody recognizes Human antigen. The REST Antibody, HRP conjugated has been shown to work in the following applications: EIA, Immunoassay, and ELISA.
Description
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression