The DNA Ligase IV Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to DNA Ligase 4, and LIG4. This antibody recognizes Human antigen. The DNA Ligase IV Rabbit mAb Antibody has been shown to work in the following applications: Western Blot.
Description
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends