The RAN Conjugated Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Ran. This antibody recognizes Human, Mouse, and Rat antigen. The RAN Conjugated Antibody has been shown to work in the following applications: Other.
Description
Ran is a small GTPase of the Ras family that plays a central role in the spacial and temperal organization of eukaryotic cells. During interphase, Ran-GDP localizes to the cytoplasm and Ran-GTP to the nucleus. This polarized localization of Ran ensures its role in nuclear transport (1). During mitosis, Ran-GTP is chromatin associated, where it promotes spindle assembly and nuclear envolope formation (1, 2). In S phase, Ran-GTP associates with and inhibits MCM helicase, ensuring precise chromosomal DNA duplication during the cell cycle (3)