The Rabbit Anti-AMPK alpha1/2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, Rat, and Non-Human Primate antigen. The Rabbit Anti-AMPK alpha1/2 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
AMPK (for 5'-AMP-activated protein kinase) is a heterotrimeric complex comprising a catalytic A subunit and regulatory B and G subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation.Activated AMPK can phosphorylate and regulate in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively.
This product can be used in analytical tools such as Western Blot, IHC-p, Immunofluorescence, ELISA