The Rb Antibody (Ser780) from MyBioSource.com is a Rabbit Polyclonal antibody. The Rb Antibody (Ser780) has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
Rb is phosphorylated to pRb by certain Cyclin Dependent Kinases (CDKs). pRb is described as being hyperphosphorylated and when in this state, it is unable to complex E2F and therefore, unable to restrict progression from the G1 phase to the S phase of the cell cycle. During the M-to-G1 transition, pRb is progressively dephosphorylated by PP1, returning to its growth-suppressive hypophosphorylated state Rb