The CLECSF6 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CLEC4A. This antibody recognizes Human antigen. The CLECSF6 Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca (2+)-dependent manner (PubMed:10438934). Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8 (+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8 (+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 (PubMed:20530286). In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (PubMed:18258799). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:10438934)