MyBioSource.com's Anti-Human CD8a APC is a Mouse monoclonal antibody. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a type I transmembrane glycoprotein of 32-34 kDa. CD8alpha is a member of the Ig superfamily, expressed as a homodimer (CD8alphaalpha) or as a heterodimer (CD8alphabeta). CD8+ alphabeta T lymphocytes express both CD8alphaalpha and CD8alphabeta, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.
OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitope or block each other by steric hindrance