MyBioSource.com's Anti-Hu CD18 Purified Low Endotoxin is a Mouse monoclonal antibody. The Anti-Hu CD18 Purified Low Endotoxin Antibody was generated using ITGB2 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Assay, Flow Cytometry, Functional Assay, Immunoprecipitation, and Western Blot.
Description
CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis