MyBioSource.com's Phospho-SHP2 (Tyr546) Rabbit pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Phospho-SHP2 (Tyr546) Rabbit pAb Antibody was generated using protein tyrosine phosphatase non-receptor type 11, and PTPN11 as the antigen and it reacts with Human.
Description
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed: 28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed: 28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed: 26742426)