The EP3 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PTGER3. This antibody recognizes Human antigen. The EP3 Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, and Western Blot.
Description
Receptor for prostaglandin E2 (PGE2)(PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G (i) proteins, and to an elevation of intracellular calcium (PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3 (-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-inducedulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity)