The Anti-CD3/CD4/CD8a Antibody from MyBioSource.com Monoclonal antibody. This antibody recognizes Human antigen. The Anti-CD3/CD4/CD8a Antibody has been shown to work in the following applications: Cell Sorting, Isolation, Flow Cytometry, and Immunofluorescence.
Description
This product is a FCM antibody cocktail made up of APC Anti-Human CD3 Antibody [Clone: OKT-3](Mouse IgG2a, kappa), FITC Anti-Human CD4 Antibody [Clone: RPA-T4](Mouse IgG1, kappa) and PE Anti-Human CD8a Antibody [Clone: OKT-8](Mouse IgG2a, kappa).CD3 is a heterotetrameric protein consisting of a CD3gamma, a CDdelta and 2 CD3epsilon. It forms complex with TCR. OKT-3 recognize human CD3epsilon. Human CD3 is expressed on the surface of T cells and NKT cells.CD4 is also called Leu-3 or T4. It's a single-chain type I transmembrane glycoprotein, mainly expressed on the surface of T cells, and monocytes/macrophages. In T cells, CD4 forms complex with TCR/CD3 and play important roles in T cell immunity. The target of HIV is CD4+ T cells. Reduction of CD4+ T cells is the main reason of defected immunity after HIV infection.CD8 is mainly expressed on cytotoxic T cells and also some subpopulations of NK cells. CD8 forms dimer function. In most cells, CD8 is a heterodimer consisting of CD8a and CD8b, but in NK cells nearly all CD8 is homodimer of CD8a. CD8a can form co-receptor with MHC-I restricted TCR to promote T cell antigen recognition and activation