The Granzyme B Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Granzyme B, and GZMB. This antibody recognizes Human, Mouse, and Rat antigen. The Granzyme B Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis