The SHP2 Rabbit pAb Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to protein tyrosine phosphatase non-receptor type 11, and PTPN11. This antibody recognizes Human antigen. The SHP2 Rabbit pAb Antibody has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed: 28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed: 28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed: 26742426)