The Integrin alpha5 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ITGA5. This antibody recognizes Human, Mouse, and Rat antigen. The Integrin alpha5 Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Integrin alpha-5/beta-1 (ITGA5: ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5: ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). ITGA5: ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). ITGA5: ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430)