MyBioSource.com's GFAP Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot. The GFAP Antibody was generated using GFAP, and Glial Fibrillary Acidic Protein as the antigen and it reacts with Human, Mouse, and Rat.
Description
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined.
Function: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Subunit Structure: Interacts with SYNM (By similarity). Isoform 3 interacts with PSEN1 (via N-terminus).
Post-translational Modifications: Phosphorylated by PKN1.
Similarity: Belongs to the intermediate filament family