The ASAH3 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ACER1. This antibody recognizes Human antigen. The ASAH3 Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:20207939, PubMed:20628055). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). May also hydrolyze dihydroceramides to produce dihydrosphingosine (PubMed:20628055). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:17713573)