The Anti-Hu CD11c Purified Antibody from MyBioSource.com is a Mouse Monoclonal antibody to ITGAX. This antibody recognizes Human, and Non-Human Primate antigen. The Anti-Hu CD11c Purified Antibody has been shown to work in the following applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry - frozen, and Immunoprecipitation.
Description
CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b