The GPR40 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to FFAR1, and free fatty acid receptor 1. This antibody recognizes Human, and Non-Human Primate antigen. The GPR40 Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, and Western Blot.
Description
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G (q) and G (i)-mediated pathway