The Rabbit Anti-WEE1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to WEE1 G2 checkpoint kinase (WEE1). This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-WEE1 Antibody has been shown to work in the following applications: Other.
Description
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation