The IDH2 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to IDH2, and isocitrate dehydrogenase (NADP(+)) 2. This antibody recognizes Human, Mouse, and Rat antigen. The IDH2 Polyclonal Antibody has been shown to work in the following applications: Precipitation, ChIP, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants