The Rabbit Anti-hnRNP C1/2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to heterogeneous nuclear ribonucleoprotein C (HNRNPC). This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-hnRNP C1/2 Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6- methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm (6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671)