The NF-kB p65/RelA Rabbit pAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to BDNF, and Brain Derived Neurotrophic Factor. This antibody recognizes Human, Mouse, and Rat antigen. The NF-kB p65/RelA Rabbit pAb Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene