MyBioSource.com's Integrin beta4 Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Integrin beta4 Polyclonal Antibody was generated using ITGB4 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6: ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6: ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6: ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464)