The Caspase 9 Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to CASP9, and Caspase 9. This antibody recognizes Human, and Mouse antigen. The Caspase 9 Rabbit mAb Antibody has been shown to work in the following applications: Western Blot.
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9