The Rabbit Anti-MRE11 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MRE11. This antibody recognizes Human antigen. The Rabbit Anti-MRE11 Antibody has been shown to work in the following applications: Western Blot.
Description
MRE11 and NBS1 function together as components of a MRE11/RAD5/NBS1 protein complex. The MRN complex consisting of MRE11A-RAD5-NBS1 proteins is involved in the repair of double-strand breaks, and mutations in genes coding for the MRN complex have been identified in families with breast and ovarian cancer. In human-synovium chimeric mice, MRE11A(low) T cells were tissue-invasive and pro-arthritogenic, and MRE11A reconstitution mitigated synovitis.MRE11A is a therapeutic target to combat immune aging and suppress dysregulated tissue inflammation