The Anti-FoxP3 PE Antibody from MyBioSource.com is a Mouse Monoclonal antibody to Forkhead Box P3, and FOXP3. This antibody recognizes Human, and Mouse antigen. The Anti-FoxP3 PE Antibody has been shown to work in the following applications: Flow Cytometry.
Description
FoxP3 (Forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome