MyBioSource.com's 3beta-HSD7 Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The 3beta-HSD7 Polyclonal Antibody was generated using HSD3B7 as the antigen and it reacts with Human, Mouse, and Rat.
Description
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C (19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha, 25-dihydroxycholesterol (7- alpha, 25-OHC):7-alpha, 25-OHC acts as a ligand for the G protein- coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells