The Rabbit Anti-IkappaB-beta Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NFKB inhibitor beta, and NFKBIB. This antibody recognizes Human antigen. The Rabbit Anti-IkappaB-beta Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation