The Rabbit Anti-Bcl-2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to BCL2, and BCL2 apoptosis regulator. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-Bcl-2 Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785)