MyBioSource.com's Histone H4 Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Histone H4 Polyclonal Antibody was generated using H4 clustered histone 15, H4 clustered histone 8, H4 histone 16, H4-16, H4C15, and H4C8 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling