MyBioSource.com's Anti-Hu CD62P FITC is a Mouse monoclonal antibody. The Anti-Hu CD62P FITC Antibody was generated using Selectin P, and Selp as the antigen. It reacts with Human, and Non-Human Primate. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster