MyBioSource.com's CaValpha2delta1 Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The CaValpha2delta1 Polyclonal Antibody was generated using CACNA2D1 as the antigen and it reacts with Rat.
Description
CACNA2D1 (Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1) is a Protein Coding gene. Diseases associated with CACNA2D1 include Familial Short Qt Syndrome and Timothy Syndrome. Among its related pathways are CCR5 Pathway in Macrophages and PEDF Induced Signaling. GO annotations related to this gene include voltage-gated calcium channel activity and calcium channel regulator activity. An important paralog of this gene is CACNA2D2.The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion