The IkappaB-alpha Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NFKBIA. This antibody recognizes Human, Mouse, and Rat antigen. The IkappaB-alpha Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription