CXCR6 Antibody - BSA Free NLS1102 from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemCXCR6 Antibody - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $429.00Supplier Page View Company Product Page
Catalog NumberNLS1102
Concentration1.0 mg/ml
ApplicationsFlow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence
FormatPBS
Conjugate/TagUnconjugated
ReactivityHuman,Monkey,Mouse
TargetCXCR6
Quantity0.05 ml
HostRabbit
ImmunogenSynthetic 16 amino acid peptide from 2nd cytoplasmic domain of human CXCR6
ClonalityPolyclonal
PurityImmunogen affinity purified
Research AreaChemokines and Cytokines, Cytokine Research, GPCR, Immunology, Innate Immunity, Virology Bacteria and Parasites
IsotypeIgG
Antibody TypePrimary Antibodies
StorageKeep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles
NCBI Full Gene NameC-X-C motif chemokine receptor 6
NCBI Gene AliasesBONZO, CD186, CDw186, STRL33, TYMSTR

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Human CXCR6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Sizes Available: 0.05 ml

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Questions and Answers

Can this antibody be used to study the role of CXCR6 in lung cancer immunotherapy?

Yes, the CXCR6 Antibody has been utilized in research examining the role of CXCR6-positive CD8+ mucosal-associated invariant T cells in non-small cell lung cancer. In a study, it was shown that high expression of CXCR6 on CD8+ T cells correlates with better progression-free survival in patients undergoing anti-PD-1 therapy, indicating its potential as a biomarker for immunotherapy response ().

Is this antibody effective for detecting CXCR6 in immunofluorescence assays?

The CXCR6 Antibody has been successfully employed in multiplex immunofluorescence assays, where it was used to stain CD8+ T cells in tumor tissues. The study demonstrated that CXCR6 expression is critical for the antitumor efficacy of CD8+ T cells, highlighting its utility in immunofluorescence applications ().

What species can this antibody be used on for research purposes?

The CXCR6 Antibody is reactive with multiple species, including human, mouse, and non-human primate samples. This broad reactivity allows for its application in various experimental models across different species.

How does the CXCR6 Antibody contribute to understanding T cell responses in cancer?

Research has indicated that CXCR6 is specifically expressed on intratumoral CD8+ T cells, which are essential for effective immune responses against tumors. The antibody can help identify and characterize these cells, providing insights into their role in mediating cancer regression and improving the efficacy of immunotherapies ().

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) CXCR6+ T cells promote apoptosis and necroptosis in proximal tubules during AKI-to-CKD transitionCell Death & DiseaseMarch 24, 2026Xiaoxu Li, Isabel Melchinger, Yuchu Chen, Jiankan Guo, Lloyd G. Cantley, Leyuan XuTUNEL-fluorescein (#11684795910, Roche), LTL-fluorescein (#L32480, Thermo Fisher Scientific), CXCR6 (#NLS1102, Novus Biologicals), and F4/80 (#MCA497, Bio-Rad), respectively. The sections were counterstained with

(2) Recruited brain tumor-derived mesenchymal stem cells contribute to brain tumor progressionStem CellsJanuary 1, 0001"Behnan J, Isakson P, Joel M, Cilio C, Langmoen IA, Vik-Mo EO, Badn W."

(3) Recruitment of mesenchymal stem cells into prostate tumours promotes metastasisNature communicationsJanuary 1, 0001"Jung Y, Kim JK, Shiozawa Y, Wang J, Mishra A, Joseph J, Berry JE, McGee S, Lee E, Sun H, et al."

(4) CXCR6-positive circulating mucosal-associated invariant T cells can identify patients with non-small cell lung cancer responding to anti-PD-1 immunotherapyJournal of experimental & clinical cancer research : CRJanuary 1, 0001"Qu J, Wu B, Chen L, Wen Z, Fang L, Zheng J, Shen Q, Heng J, Zhou J, Zhou J."primary antibodies targeting CD8 (Ab237709, Abcam; 1:2000), TCR Vα7.2(351726, Biolegend; 1:200), CXCR6 (NLS1102, Novus; 1:200) followed by Opal Polymer HRP Ms + Rb (Akoya Biosciences). Samples were subjected to optical

(5) CXCR6 is required for antitumor efficacy of intratumoral CD8(+) T cellJournal for immunotherapy of cancerJanuary 1, 0001"Wang B, Wang Y, Sun X, Deng G, Huang W, Wu X, Gu Y, Tian Z, Fan Z, Xu Q, et al."antihuman CD8 (Cell Signaling Technology Cat# 70306, RRID:AB_2799781), rabbit antihuman CXCR6 (Novus Cat# NLS1102, RRID:AB_10000951), goat antimouse CXCL16 (R&D, Cat# AF503-SP), goat antirabbit IgG (H+L) Alexa Fluor

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