The IP3R-I Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ITPR1. This antibody recognizes Human, Mouse, and Rat antigen. The IP3R-I Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1, 4, 5- trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity)