MyBioSource.com's Anti-Hu CD49d PE is a Mouse monoclonal antibody. The Anti-Hu CD49d PE Antibody was generated using ITGA4 as the antigen. It reacts with Human, Bovine, Canine, Feline, Horse, Non-Human Primate, and Sheep. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer's patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins