MyBioSource.com's SARS-COV-2 Spike RBD (Omicron) Protein pAb is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The SARS-COV-2 Spike RBD (Omicron) Protein pAb Antibody was generated using CD2BP2 as the antigen and it reacts with 2019-nCoV, Corona Virus, Coronavirus, COVID-19, SARS-CoV-2, and Virus.
Description
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It''s been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate